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Skin Renewal Complex — collagen from within
EscapeMed · Skin Renewal Complex

Not collagen powder.
Cofactors for collagen.

14 ingredients for collagen synthesis from within. Chronobiologically placed in the post-cortisol window — when fibroblasts are naturally most active.

Order Skin Renewal Complex
14
active ingredients
5
biological layers
8–12
weeks for visible results
🌤
morning · 8–11 AM
Problem

Collagen powder
is not enough

Collagen is the most abundant protein in the body — ~30% of all proteins. It forms the foundation of skin, bones, tendons, ligaments and blood vessels.

But exogenous collagen (in powder or capsules) is not directly incorporated into new collagen fibres. The body synthesises collagen itself — from amino acid building blocks — through an enzymatic cascade that requires specific cofactors at each stage.

A deficiency of a single cofactor stops the entire synthesis, no matter how many building blocks you have.

"Without cofactors, amino acid building blocks remain only building blocks — a wall without mortar."

Collagen decline with age

After 25
−1%
After 40
−1.5%
After 50
−30%*

*in the first 5 years after menopause

Annual decline ~1% after age 25

Chronobiology

Why morning 8–11 AM?

Fibroblasts — the cells that synthesise collagen — follow a circadian rhythm. Their activity peaks in the post-cortisol window, when cortisol naturally drops after its morning peak.

⏰

6–8 AM

Cortisol peaks — body in activation mode

🌤

8–11 AM ← OPTIMAL

Cortisol declining — fibroblasts activate, collagen synthesis is triggered

🌙

At night

Collagen renewal — supported by Magnesium PM and Super Sleep

🔬

Skin Renewal Complex is, to our knowledge, the first chronobiologically placed formula with all cofactors for collagen synthesis, documented in the scientific literature. → Read: Skin Renewal Complex Research

Formula

14 ingredients.
One complete system.

Each ingredient has a precise role in collagen synthesis, tissue protection or hydration. Nothing is accidental.

Vitamin C (L-ascorbic acid)
Mandatory cofactor for hydroxylation of proline and lysine — without it, collagen synthesis does not proceed regardless of available building blocks.
EU: contributes to normal collagen formation*
Zinc bisglycinate
Cofactor for collagenases and MMP inhibition — regulates breakdown of old fibres. Antiandrogen effect balances the high biotin dose.
EU: contributes to normal collagen* · hair* · nails*
Biotin (2.5 mg)
Supports the keratin structure of hair and nails. The high dose is balanced with zinc and antioxidants — does not cause acne.
EU: maintenance of normal hair* · nails*
Hyaluronic acid
Maintains intercellular space and dermal hydration. Supports skin elasticity and plumpness.
Support for dermal hydration
MSM (organic sulfur)
Sulfur is a structural component of collagen fibres — disulfide bridges between collagen chains. Irreplaceable for firmness.
Structural support for connective tissue
Glutathione (reduced)
The most important intracellular antioxidant. Protects fibroblasts from oxidative stress, which breaks down collagen faster than the body can produce it.
Cellular protection and antioxidant defence
NAC (N-acetyl cysteine)
Glutathione precursor — replenishes stores when depleted. Anti-inflammatory action reduces collagen breakdown.
Support for glutathione synthesis
Coenzyme Q10
Mitochondrial energy for fibroblasts. Its natural level declines with age — after age 40 supplementation is particularly relevant.
Cellular energy and antioxidant protection
Astaxanthin
The most powerful known carotenoid antioxidant — 6000x more potent than vitamin C for lipid peroxidation. Protects collagen fibres from UV damage from within.
Photoprotective antioxidant protection
Vitamin E (alpha-tocopherol)
Lipophilic antioxidant, protects cell membranes and acts synergistically with vitamin C and astaxanthin.
EU: contributes to the protection of cells*
Selenium (selenomethionine)
Cofactor for glutathione peroxidase — a key enzyme for recycling glutathione. Without it, glutathione stores drop.
EU: contributes to normal glutathione synthesis*
Copper bisglycinate
Cofactor for lysyl oxidase — the enzyme that cross-links collagen fibres into mature fibres. Without copper, fibres are weak and disorganised.
EU: contributes to normal collagen*
Niacin (vitamin B3)
NAD+ precursor — energy cofactor for fibroblasts. Supports cellular renewal and DNA repair.
EU: contributes to normal metabolism*
Vitamin B6 (pyridoxal-5-phosphate)
Active form of B6 — cofactor for amino acid metabolism. Supports tryptophan conversion and elastin synthesis.
EU: normal psychological function*

* EU-approved health claim under Regulation (EC) 1924/2006

Frequent question

Biotin 2.5 mg —
why doesn't it cause acne?

Biotin at high doses theoretically competes with pantothenic acid (B5) for absorption, which could increase sebum production. But Skin Renewal Complex is formulated to neutralise that effect.

The formula contains zinc bisglycinate — with proven anti-acne action via three independent mechanisms:

1

Reduces sebum — the antiandrogen effect of zinc regulates sebaceous gland activity

2

Antimicrobial action — zinc inhibits the growth of C. acnes bacteria

3

Anti-inflammatory — glutathione, NAC, astaxanthin and vitamin C reduce the inflammatory environment

Individuals with markedly acne-prone skin start with 1 capsule/day and gradually increase.

Biotin in Skin Renewal Complex

2.5 mg
5000% NRV
EU-approved health claim*
  • ✓Maintenance of normal hair*
  • ✓Maintenance of normal nails*
  • ✓Cofactor for keratinisation of the hair shaft
  • ✓Proven role in brittle nail syndrome

There are no controlled RCTs proving a causal link between biotin and acne. Existing evidence is anecdotal. The formula is designed to preventively neutralise this risk.

Comparison

Collagen powder
or cofactors for collagen?

Collagen powder / peptides

  • Provides building blocks (amino acids)
  • Contains no cofactors for synthesis
  • Absorption and incorporation are limited
  • No circadian timing
  • No antioxidant protection
  • No support for fibroblasts

Skin Renewal Complex

  • 14 cofactors for the body's own synthesis
  • The full enzymatic pathway covered
  • Placed in the fibroblast window 8–11 AM
  • Antioxidant protection (glutathione, NAC, astaxanthin)
  • Hydration (hyaluronic acid)
  • Hair and nails (biotin, zinc, selenium)

Both together? Collagen powder (amino acid building blocks) and Skin Renewal Complex (cofactors) complement each other — they don't compete. The body gets building blocks from a protein-rich diet. Skin Renewal Complex provides what food cannot replace.

Expectations

When will you notice the difference?

Biology works in cycles. Skin renews in 28–40 days, collagen transformation takes 8–12 weeks.

1

Month 1

Days 1–30 · Foundation
  • Antioxidant defence is established
  • Hydration improves — skin looks "fresher"
  • Nails become harder after 4–6 weeks
  • Collagen synthesis is triggered — results not yet visible
2

Month 2

Days 31–60 · Transformation
  • First changes in skin texture
  • Glow returns — reduced oxidative stress
  • Hair shows the first signs of strengthening
  • Elasticity slowly improves
3

Month 3

Days 61–90 · Full results
  • Collagen transformation visible — elasticity, structure
  • Hair and nails noticeably strengthened
  • Skin better supplied with cofactors for renewal
  • 90 days is the full biological cycle
For whom

Skin Renewal Complex
is for you if

🌸

You are in perimenopause or over 40

Declining estrogen accelerates collagen loss — up to 30% in the first 5 years after menopause. This is the period when collagen support matters most.

✦

Skin is losing glow and elasticity

The first visible signs of skin aging are often a sign of declining collagen — not a lack of moisture, but a lack of synthesis from within.

💇

Hair is thinner or falling out

Biotin, zinc and selenium are key for the keratin structure and the collagen matrix of the hair follicle. Visible changes after 8–12 weeks.

💅

Nails are brittle or slow growing

Nails are mostly keratin with a collagen base. Biotin and zinc are EU-approved for maintenance of normal nails.*

🌿

You feel well — prevention

Collagen synthesis declines from age 25 onwards. Preventive support of cofactors is an investment that pays off in 10 years.

🦴

You have joint or cartilage issues

Type II collagen is the basis of cartilage. MSM, vitamin C and copper support the integrity of connective tissue, mobility and recovery after exertion.

🏋️

You train actively

Physical activity increases the need for collagen in tendons, ligaments and cartilage. MSM and vitamin C support the recovery of connective tissue after exertion.

🦴

You have joint or cartilage issues

Type II collagen is the basis of cartilage. Cartilage renews slowly — 8–12 weeks. MSM, vitamin C and copper support the integrity of connective tissue and mobility.

🧬

You have genetically higher needs

COL1A1, COL3A1 or ESR1 variants mean structurally weaker connective tissue and a higher intake of cofactors to maintain integrity. Not a disease — a biological predisposition.

Frequent questions

What people most often ask

Collagen powder provides the amino acid building blocks for renewal. But the body synthesises collagen itself — through an enzymatic cascade that requires specific cofactors. Without vitamin C, synthesis does not proceed. Without copper, fibres are disorganised. Without glutathione, oxidative stress breaks them down faster than they form. Skin Renewal Complex provides exactly those cofactors. Both together work better than either alone.
In the morning between 8 and 11 AM — in the post-cortisol window, when fibroblasts reach their natural peak of activity. Astaxanthin and CoQ10 are absorbed better with fats, so we recommend taking it with a meal. This is one of the few formulas with a clear chronobiological rationale for timing.
This is a common concern — and a legitimate one. Isolated high doses of biotin do affect the skin in some individuals. However, Skin Renewal Complex contains zinc bisglycinate (antiandrogen effect), vitamins C and E and astaxanthin (anti-inflammatory) and NAC with glutathione — ingredients that act in the opposite direction of any pro-acne effect of biotin. In practice we have not observed this. Individuals with markedly acne-prone skin should start with one capsule.
Yes, the capsules are HPMC — suitable for vegans and vegetarians. Free from gluten, milk, eggs, nuts. Non-GMO. No animal origin. Manufactured in a certified GMP facility in the EU.
It combines excellently with Magnesium AM (together they cover the morning collagen window) and Super Sleep (which supports nightly renewal). Collagen powder is a welcome addition — not a competitor. Continue omega-3 and vitamin D separately.

A question? info@escapemed.si

Check at home

3 signs the body shows early

Your body often shows changes in collagen early. Three simple checks.

Hypermobility test for collagen

Mobility test

Hypermobility often indicates COL1A1/COL3A1 variants — connective tissue is structurally weaker and requires a higher intake of cofactors.

Pinch test for skin elasticity

Pinch test

Pinch the skin on the cheek or back of the hand, pull and release. A slow return indicates a weakened collagen-elastin network.

Tear trough — sign of collagen volume loss

Tear trough

A deep shadow from the inner corner of the eye downward is a sign of loss of collagen volume in the periorbital tissue.

These tests are not a medical diagnosis — they are observational tools for understanding your own body.

Laser rejuvenation and Skin Renewal Complex
Synergy

Aesthetic procedures +
Skin Renewal Complex

Laser procedures, microneedling, radiofrequency and biostimulators activate fibroblasts through controlled tissue micro-injury. But an activated fibroblast cannot synthesise collagen without cofactors.

Skin Renewal Complex provides exactly what activated fibroblasts need in the following hours and days — vitamin C, copper, MSM, glutathione and NAC. Cofactors support the regenerative processes that follow the procedure. We describe the biological mechanisms of the ingredients — we do not claim the product improves procedure outcomes.

✦

Before the procedure: cofactor saturation optimises the fibroblast response to the stimulus

✦

During recovery: glutathione, NAC and astaxanthin reduce the inflammatory response and accelerate regeneration

✦

Long term: consistent intake maintains fibroblast activity between procedures

Skin Renewal Complex is not a substitute for aesthetic procedures — it is the foundation that makes procedures more effective. A signal without building material is like a construction site without mortar.

→ Skin Fitness Framework — AMWC Monaco 2026
Holistic approach

Collagen is not just a capsule

Skin Renewal Complex is support — not a replacement for a healthy lifestyle. What supports and what breaks down collagen.

✓ Supports collagen

  • ✓Quality sleep — nightly renewal of skin and connective tissue
  • ✓Protein food — glycine, proline, lysine as building blocks
  • ✓Hormonal balance — estrogen activates fibroblasts
  • ✓Movement — mechanical load adapts connective tissue
  • ✓Sun protection — reduces oxidative stress of the skin
  • ✓Aesthetic protocols — microneedling, lasers, RF activate fibroblasts

✗ Breaks down collagen

  • ✗Chronic stress — cortisol accelerates collagen breakdown
  • ✗UV radiation without protection — photoaging and MMP activation
  • ✗Smoking — reduces oxygenation and activates MMP
  • ✗Excess sugar — glycation of collagen fibres
  • ✗Sleep deprivation — reduced growth hormone synthesis at night
  • ✗Cofactor deficiency — the enzymatic cascade stops
Entry point

Where do you have the greatest concern?

Skin Renewal Complex works on all four levels at once — you start where you feel the greatest need.

Skin

Skin

Losing glow, elasticity or ageing faster. Vitamin C, glutathione and astaxanthin support fibroblast renewal.

Order →
Hair

Hair

Thinner, less dense or growing more slowly. Biotin 2.5 mg, MSM and zinc support the keratin structure.* Results after 8–12 weeks.

Order →
Nails

Nails

Brittle, slow growing or splitting. Biotin and zinc — EU-approved health claim for maintenance of normal nails.* After 6–8 weeks.

Order →
Joints

Joints

Morning stiffness or slower recovery after exercise. MSM, vitamin C and copper support the integrity of cartilage and connective tissue.

Order →

* EU-approved health claim under Regulation (EC) 1924/2006

Packages

Choose your cycle

Collagen biology needs time. 30 days to start. 90 days to be seen.

30 days

€59

≈ €1.97 / day

  • ✓60 vegetarian capsules
  • ✓Entry point
  • ✓30-day guarantee
Order 30D
RECOMMENDED

90 days

€177

≈ €1.57 / day · −20%

  • ✓180 vegetarian capsules
  • ✓Full collagen cycle
  • ✓Hair growth cycle · joints · skin
  • ✓Free shipping
Order 90D

60 days

€118

≈ €1.77 / day · −10%

  • ✓120 vegetarian capsules
  • ✓Visible first results
  • ✓Free shipping
Order 60D

Prices are indicative. Check current prices at escapemed.si.

Start with Skin Renewal Complex

14 cofactors. One morning. Collagen from within — not from powder.

Order Skin Renewal Complex Discover the full system
* EU-approved health claim under Regulation (EC) 1924/2006. · Food supplements are not medicinal products. They are not intended to diagnose, treat or prevent disease. · EscapeMed d.o.o. · info@escapemed.si